Understanding Epilepsies with In Vitro Disease Models
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Epilepsy, a prevalent neurological disorder, manifests as recurrent unprovoked seizures across various syndromes. Despite advancements in antiepileptic drugs, a significant proportion of patients remain unresponsive to current treatments, highlighting the need for novel therapeutic avenues.
At NeuroProof, we address this challenge with cutting-edge in vitro screening assays designed to probe the mechanisms of epileptogenesis and evaluate the efficacy of emerging antiepileptic compounds. Our assays offer a deeper understanding of the epileptic condition and aid in the development of targeted therapies.
Our Approach:
- Diverse Assay Models: We have developed specialized in vitro models tailored with our MEA approach and sophisticated data analysis to investigate different aspects of epilepsy, including:
- 4-AP Model: Mimics epileptiform activity induced by 4-aminopyridine, aiding in the study of seizure mechanisms.
- SCN1A Model: Focuses on mutations in the SCN1A gene associated with Dravet syndrome, a severe form of epilepsy.
- Developmental Model: Explores the impact of developmental factors on epileptogenesis, offering insights into early intervention strategies.
- Human iPSC-Derived Neurons: Our assays leverage human induced pluripotent stem cell (iPSC) technology, enhancing translational relevance and facilitating drug discovery in a human-specific context.
- Comprehensive Analysis: Utilizing advanced classification algorithms, we assess the excitatory or pro-convulsive potential of test compounds. Our side-effect assays provide valuable insights into compound safety profiles.
- Probing Pro-Convulsive Mechanisms: Our technology enables the investigation of pro-convulsive compounds such as picrotoxin, shedding light on their effects on network activity and ictal-like discharges in frontal cortex cultures.
Why Choose NeuroProof:
- Expertise: Our team comprises experts in neuroscience, pharmacology, and assay development, dedicated to advancing epilepsy research and drug discovery.
- Innovation: We continuously refine our assays and technologies to stay at the forefront of epilepsy research, offering state-of-the-art solutions to our clients.
- Collaboration: We welcome collaborations with research institutions, pharmaceutical companies, and biotech firms to accelerate the development of novel therapies for epilepsy.
Contact Us:
For further information on our epilepsy assays and how they can drive your research forward.